One of the mysteries of the English language finally explained.
1‘much to his annoyance, Louise didn't even notice’
irritation, exasperation, vexation, indignation, anger, crossness, displeasure, chagrin, pique
2‘the council found him an annoyance’
nuisance, source of irritation, pest, bother, trial, irritant, inconvenience, menace, thorn in one's flesh
informal pain, pain in the neck, bind, bore, headache, hassle
Scottish informal nyaff, skelf
North American informal pain in the butt, nudnik, burr in someone's saddle, burr under someone's saddle
Australian informal fair cow
NZ Australian informal nark
British vulgar slang pain in the arse
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