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An inherited disorder characterized by a tendency to bleed, caused by deficiency or abnormality of a plasma coagulation factor (von Willebrand factor).
- ‘The most commonly encountered disorders are coagulation factor VIII deficiency, coagulation factor IX deficiency and von Willebrand's disease.’
- ‘Bloat, epilepsy and heart related problems are also reported, as are von Willebrand's disease and hemophilia A.’
- ‘In most patients with von Willebrand disease, factor VIII activity and plasma levels of von Willebrand factor are decreased.’
- ‘Patients with Type 3 (and some with Type 2A and 2B) will need treatment with humate p, a medication derived from human plasma that contains both factor VIII and von Willebrand factor.’
- ‘There is also impairment of the platelet response to thrombin, collagen, fibrinogen, and von Willebrand factor.’
1940s: named after Erik A. von Willebrand (1870–1949), Finnish physician.
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