Definition of vincristine in English:

vincristine

noun

Medicine
  • A cytotoxic compound of the alkaloid class obtained from the Madagascar periwinkle and used to treat acute leukemia and other cancers.

    • ‘What benefits the willow tree that its bark should contain salicylic acid; or the foxglove, digitalis; the periwinkle, vincristine; or the poppy, opiates?’
    • ‘The patient was treated with a combined cyclophosphamide, vincristine, and prednisone chemotherapy regimen, resulting in a partial response.’
    • ‘The patient was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy starting in August 1998.’
    • ‘In reality, more than 30% of conventional medications come from common plant sources (eg, digitalis from foxglove, vincristine from periwinkle).’
    • ‘Some types of medications used include azathioprine, vincristine, cyclophosphamide, cyclosporine or vinblastine.’
    • ‘The types of drugs used are vincristine (from periwinkles), prednisone (a steroid), asparaginase (an enzyme) or daunorubicin (an antibiotic).’
    • ‘The chemotherapy agents used were combinations of methotrexate, mitoxantrone hydrochloride, cyclophosphamide, vincristine, etoposide and prednisolone, ranimustine and enocitabine, and carboplatin.’
    • ‘She underwent 6 cycles of cyclophosphamide, doxorubicin, vincristine sulfate, and prednisone chemotherapy and obtained remission.’
    • ‘Of the plant-derived anticancer drugs in clinical use, the best known are the alkaloids vinblastine and vincristine, isolated from the Madagascar periwinkle, Catharanthus roseus.’
    • ‘She was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone and had a good initial response.’
    • ‘The medication vincristine has been used widely and successfully to treat cancer for many years, but sometimes the medication is mistakenly administered in the sac around the spinal cord (ie, intrathecal) instead of intravenously.’
    • ‘Nitrofurantoin, dapsone, metronidazole, isoniazid, disulfiram, amiodarone, vincristine, cisplatin, Taxol, phenytoin, chloramphenicol, hydralazine, and high-dose pyridoxine can all lead to neuropathies.’
    • ‘Treatment consisted of intrathecal methotrexate via Omaya reservoir followed by systemic CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy and whole brain irradiation.’
    • ‘Digoxin, morphine, ephedrine, vincristine, ergotamine, bromocriptine, and others are carefully tested and standardized drugs from plants.’
    • ‘The patient was treated per the hyper-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) with intrathecal prophylaxis and achieved a complete remission.’
    • ‘Combined chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone was initiated.’
    • ‘The patient was treated initially with prednisone, vincristine, adriamycin, and intrathecal methotrexate.’
    • ‘He received treatment with multiagent chemotherapy that consisted of vincristine, doxorubicin, cyclophosphamide, and prednisone.’
    • ‘The patient experienced a complete remission while receiving hyperfractionated cyclophosphamide, vincristine, adriamycin, dexamethasone chemotherapy, and she has remained in complete remission for more than 7 months.’
    • ‘Our patient did not respond to cyclophosphamide, doxorubicin, vincristine, and prednisone combination therapy as has been the experience with all other patients with PEL.’

Origin

1960s: from modern Latin Vinca (see vinca) + a second element perhaps based on crista + -ine.

Pronunciation:

vincristine

/vinˈkrisˌtēn/