1 Ascertain the amount of a constituent in (a solution) by measuring the volume of a known concentration of reagent required to complete a reaction with it, typically using an indicator.
- ‘This solution was titrated with the HSA fragment by adding small amounts of an ~ 0.3 mM protein solution in the aqueous buffer and recording the spectrum after incubation for a few minutes after each addition.’
- ‘To determine the exact concentration, titrating the hydrochloric acid against a solution of base, for example sodium hydroxide, would be appropriate.’
- ‘A specific weight of the compound is titrated with a known concentration of acid or base until the equivalence point has been reached.’
- ‘Aliquots of the peptide solution were titrated to the micelle solution to reach a peptide-to-micelle molar ratio of 1: 220.’
- ‘The calorimetric profiles were nonlinear with increasing slope for the case when DNA was titrated into lipid solution, and the endpoint was rate dependent.’
Continuously measure and adjust the balance of (a physiological function or drug dosage)
- ‘The initial dose of ritodrine was 50 mg per minute, and then the dosage was titrated to contractions.’
- ‘In general, high doses of steroids are required, but the dosage is titrated against the response and kept to the lowest effective dose, given for as short a time as possible.’
- ‘Generally, a longer-acting benzodiazepine such as chlordiazepoxide is used, and the initial dosage is titrated downward according to blood pressure elevation, pulse rate, temperature and psychotic symptoms.’
- ‘Symptoms include abdominal discomfort, metallic taste, nausea, and diarrhea; these effects are generally transient and can be minimized by taking the drug with meals and titrating the dose slowly.’
- ‘Dosages were titrated for both medications by a treating psychiatrist at weekly follow-up visits.’
Late 19th century: from French titrer (from titre in the sense fineness of alloyed gold or silver) + -ate.