An enzyme in blood plasma that causes the clotting of blood by converting fibrinogen to fibrin.
- ‘The blood-clotting cascade ends in the formation of a substance that converts a blood protein called prothrombin into the protein thrombin, which actually forms the substance of the blood clot.’
- ‘In addition to its role in activation of fibrin clot formation, thrombin plays an important regulatory role in coagulation.’
- ‘Protective mechanisms prevent thrombin and other procoagulant enzymes from forming in healthy intact blood vessels.’
- ‘The thrombin cleaves fibrinogen to an active monomer that polymerizes to form a fibrin meshwork.’
- ‘Big, long, expensive programs against enzymes like elastase and thrombin went on year after year, but no one could get the things to quite work well enough.’
- ‘Fibrinogen is modified by thrombin to produce fibrin monomers that are the primary constituent of the fibrin clot.’
Late 19th century: from Greek thrombos blood clot + -in.