Definition of Tay–Sachs disease in US English:

Tay–Sachs disease

noun

  • An inherited metabolic disorder in which certain lipids accumulate in the brain, causing spasticity and death in childhood.

    • ‘Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found in nerve tissue called gangliosides.’

Origin

Early 20th century: from the names of Warren Tay (1843–1927), English ophthalmologist, and Bernard Sachs (1858–1944), American neurologist, who described it in 1881 and 1887 respectively.

Pronunciation

Tay–Sachs disease

/ˌtāˈsaks diˌzēz/