Definition of tamoxifen in English:



  • A synthetic drug used to treat breast cancer and infertility in women. It acts as an estrogen antagonist.

    • ‘As with all medicines, tamoxifen has side effects that may affect some women and not others.’
    • ‘About half in each of these groups were treated with chemotherapy followed by five years of tamoxifen.’
    • ‘These treatments may involve drugs such as tamoxifen, which are meant to prevent the cancer from growing again.’
    • ‘The effect found for tamoxifen also reduced the overall incidence of osteoporotic fractures of the hip, spine and radius by 19%.’
    • ‘As this history is often incomplete, our measured population of all patients on tamoxifen is grossly underestimated.’
    • ‘The authors suggest that tamoxifen may be underused in selected groups of women who could benefit from prophylaxis.’
    • ‘The risk is small compared to the benefits of using tamoxifen to treat breast cancer.’
    • ‘The question of how long patients should continue taking the drug is important because tamoxifen is not problem free.’
    • ‘We do not know if raloxifene is better than tamoxifen.’
    • ‘What are the findings from the third study, which examines switching to an aromatase inhibitor after two to three years of tamoxifen?’
    • ‘The risk did not decrease after discontinuation of tamoxifen and was not modified by other risk factors for endometrial cancer.’
    • ‘In addition to the initial therapy, most patients received tamoxifen in a dosage of 20 mg daily as adjuvant treatment.’
    • ‘This patient's doctor may be able to get her free tamoxifen.’
    • ‘However, personal history, such as abnormal biopsy, was highly correlated with the decision to take tamoxifen.’
    • ‘This crystalline retinopathy is rarely seen with standard doses of tamoxifen, but when present it can cause a substantial progressive drop in visual acuity.’
    • ‘Current treatment commonly centres on tamoxifen, another drug which shrinks tumours.’
    • ‘‘But greater use of tamoxifen has had a huge impact over the past 10 years,’ he added.’
    • ‘Patients managed as outpatients (such as those treated with tamoxifen only) were likely to be missed.’
    • ‘As a preventive measure, taking tamoxifen doesn't guarantee that you'll remain cancer-free.’
    • ‘Cataract surgery was required approximately twice as often among women who took tamoxifen.’


1970s: an arbitrary formation based on trans-, amine, oxy-, phenol, elements of the drug's chemical name.