Definition of synthase in US English:



  • often with modifier An enzyme that catalyzes the linking together of two molecules, especially without the direct involvement of ATP.

    ‘nitric oxide synthases’
    Compare with ligase
    • ‘This is plausible because the enzyme citrate synthase is localized in the mitochondrial matrix.’
    • ‘In contrast to the homotrimeric solution state of native riboflavin synthase, the enzyme was found to be monomeric in the crystal structure.’
    • ‘Production was not abrogated by inhibitors of cyclooxygenases, xanthine oxidase, nitric oxide synthases, and mitochondrial enzymes.’
    • ‘Fluorouracil induces apoptosis by inhibition of the enzyme thymidylate synthase during DNA replication.’
    • ‘This enzyme is glycogen synthase, which helps remove glucose from the blood and store it as glycogen.’