One of the mysteries of the English language finally explained.
1with object Medicine. To infect (an already infected person or animal) with a different organism; to cause superinfection of. In early use also: to reinfect (now rare).
2with object Virology. To infect (an already infected cell).
Early 20th century; earliest use found in Journal of Experimental Medicine. From super- + infect, after superinfection. Compare earlier superinfected.
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