Definition of sucralfate in US English:



  • A drug used in the treatment of gastric and duodenal ulcers. It is a complex of aluminum hydroxide and a sulfate derivative of sucrose.

    • ‘New peptic ulcers are treated with H2 blockers such as cimetidine or sucralfate (a stomach coater) and treatment of the Helicobacter infection is reserved for patients with recurrent disease in whom the organism is present.’
    • ‘After this period our patient's condition improved and we continued conservative management, which included antibiotics, omeprazole, high dose sucralfate, and intravenous feeding.’
    • ‘These trials were smaller and had a shorter follow-up but suggested H. pylori eradication was more effective than either H2 antagonists or sucralfate in treating nonulcer dyspepsia.’
    • ‘Allowing a four to six hour interval between the administration of antacids or sucralfate and fluoroquinolones avoids these interactions.’
    • ‘Antacids containing aluminum or magnesium, sucralfate, citric acid buffered with sodium citrate, or ferrous sulfate can decrease the bioavailability of trovafloxacin.’


1960s: blend of sucrose, aluminum, and sulfate (see sulfate).