Definition of screw up in US English:

screw up

phrasal verb

North American
  • Completely mismanage or mishandle a situation.

    ‘I'm sorry, Susan, I screwed up’
    • ‘If Clark screws up, the establishment is going to look pretty silly.’
    • ‘The editors are the managers, so if the paper systematically screws up, it's down to them, not the reporters.’
    • ‘Hey, an occasional friendship flub is no biggie - everybody screws up.’
    • ‘In any other situation, if an employee screws up, they get fired.’
    • ‘What I love is when the accountant screws up on a simple piece of multiplication.’
    • ‘What am I going to tell my daughter when she screws up?’
    • ‘And I know I don't hesitate to call him out when I think he's screwing up.’
    • ‘He's called me on the phone, or pulled me aside when he thought I was screwing up.’
    • ‘For most of my life, I've been in situations where people expect me to screw up.’
    • ‘I'm thinking a majority of us would rather be governed by a real human than a bunch of people who never admit to actually screwing up.’