Definition of sclerosis in US English:



  • 1Medicine
    Abnormal hardening of body tissue.

    • ‘A close-up reveals the alternating areas of sclerosis and retained hepatic parenchyma in this nutmeg liver.’
    • ‘In MS, myelin is lost in multiple areas, leaving scar tissue called sclerosis.’
    • ‘It exhibited squamous differentiation, sclerosis, and eosinophilia.’
    • ‘A doctor may suspect aortic valve sclerosis on hearing a heart murmur with a stethoscope.’
    • ‘The lymph node biopsy showed sclerosis surrounding cellular nodules that contained clusters of large atypical cells admixed with small lymphocytes and numerous eosinophils.’
    1. 1.1
  • 2Excessive resistance to change.

    ‘the challenge was to avoid institutional sclerosis’
    • ‘In other words, this is a story not about institutional sclerosis, but about the necessarily contingent process of institutional change.’


Late Middle English (originally denoting a hard external tumor): via medieval Latin from Greek sklērōsis, from sklēroun ‘harden’.