Definition of sclerosis in English:



  • 1Abnormal hardening of body tissue.

    • ‘A doctor may suspect aortic valve sclerosis on hearing a heart murmur with a stethoscope.’
    • ‘In MS, myelin is lost in multiple areas, leaving scar tissue called sclerosis.’
    • ‘The lymph node biopsy showed sclerosis surrounding cellular nodules that contained clusters of large atypical cells admixed with small lymphocytes and numerous eosinophils.’
    • ‘A close-up reveals the alternating areas of sclerosis and retained hepatic parenchyma in this nutmeg liver.’
    • ‘It exhibited squamous differentiation, sclerosis, and eosinophilia.’
    1. 1.1
      • ‘Among this latter group, there were four patients with rheumatoid arthritis, five with systemic sclerosis, three with systemic lupus erythematosus, five with dermatomyositis, and four with mixed connective tissue disease.’
      • ‘In other pathologic states, such as systemic sclerosis or diabetes, the tissue elastic properties may prove more relevant.’
      • ‘Its expression in lung tissue has been widely described in systemic sclerosis, idiopathic pulmonary fibrosis and pulmonary sarcoidosis, and bleomycin-induced lung fibrosis.’
      • ‘An association between connective tissue diseases, particularly systemic sclerosis, and gastric antral vascular ectasia has been noted.’
      • ‘The goal of treatment in patients with secondary progressive multiple sclerosis is to prevent progressive worsening of the disease.’
      • ‘The authors conclude that idiopathic pulmonary fibrosis associated with systemic sclerosis has the histopathologic pattern of nonspecific interstitial pneumonia, but that the histopathologic pattern does not predict prognosis.’
      • ‘The obstructions are due in part to shortening of the mesentery from sclerosis and impairment of the enteric blood supply, which may result in further cicatrization, kinking and narrowing.’
      • ‘The purpose of this study was to evaluate the efficacy, safety, and effect on quality of life of outpatient sclerosis using small-bore pigtail catheters.’
      • ‘Amyotrophic lateral sclerosis is a progressive disease affecting both upper and lower motor neurons.’
      • ‘Glomerular sclerosis, manifested by proteinuria, progresses as patients age.’
      • ‘Around 16% of patients with sclerosis progress to stenosis in seven years.’
      • ‘Other collagen diseases, such as progressive systemic sclerosis and systemic lupus erythematosus, are associated with increased incidence of pneumothorax.’
      • ‘Amyotrophic lateral sclerosis is a common neurologic disease associated with an inexorable decline in muscle strength.’
      • ‘A 67 year old woman with secondary progressive multiple sclerosis had a recurrence of right sided trigeminal neuralgia.’
  • 2Excessive resistance to change.

    ‘the challenge was to avoid institutional sclerosis’
    • ‘In other words, this is a story not about institutional sclerosis, but about the necessarily contingent process of institutional change.’


Late Middle English (originally denoting a hard external tumor): via medieval Latin from Greek sklērōsis, from sklēroun harden.