Definition of Santa Cruz in US English:

Santa Cruz

proper noun

  • 1A city in central Bolivia; population 1,561,061 (2009).

  • 2A port and the chief city of the island of Tenerife, in the Canary Islands; population 192,000. Full name Santa Cruz de Tenerife.

  • 3A city in west central California, on Monterey Bay; population 56,124 (est. 2008).