Definition of reagin in English:


Pronunciation: /-ɡən//rēˈājən/


  • 1The antibody that is involved in allergic reactions, causing the release of histamine when it combines with antigen in tissue, and capable of producing sensitivity to the antigen when introduced into the skin of a normal individual.

    • ‘The mother was O Rh-positive, antibody screen negative, rapid plasma reagin nonreactive, hepatitis B surface antigen negative.’
    • ‘An infant born to a seroreactive mother should be evaluated with a quantitative non-treponemal serologic test (e.g., rapid plasma reagin or VDRL).’
    • ‘An 18-year-old woman presented for her first prenatal visit at 31 weeks' gestation, at which time she was reactive for rapid plasmin reagin and had a 2 + fluorescent treponemal antibody.’
    • ‘The results of a VDRL test and rapid plasma reagin were negative.’
    • ‘Blood work, including rapid plasma reagin for syphilis and heavy metal screening, had been reported as normal.’
    1. 1.1 The substance in the blood that is responsible for a positive response to the Wassermann test.
      • ‘These tests used either complement fixation or flocculation techniques (Venereal Disease Research Laboratory [VDRL], rapid plasma reagin test, and automated reagin test).’
      • ‘The patient's angiotensin-converting enzyme level was slightly elevated, and the rapid plasma reagin test was nonreactive.’
      • ‘The rapid plasmin reagin test was negative.’
      • ‘This reaction is the basis of traditional nontreponemal tests such as the VDRL test and rapid plasma reagin test.’
      • ‘Even without a confirmatory rapid plasma reagin test or darkfield examination of the gummatous discharge, the diagnosis of secondary syphilis was obvious.’


Early 20th century: coined in German from reagieren react.