One of the mysteries of the English language finally explained.
(in testing for antigens) the range of relative quantities of precipitin (or agglutinin) and antigen within which any precipitation (or agglutination) is inhibited by the predominance of one component.
- ‘In addition, these tests may show a ‘prozone’ phenomenon in which large amounts of antibody block the antibody-antigen reaction, causing a false-negative test in the undiluted sample.’
- ‘However, highly concentrated antibodies may result in a prozone effect, leading to decreased intensity of staining.’
Early 20th century: from pro- ‘before’ + (agglutination) zone.
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