Definition of prothrombin in English:



  • A protein present in blood plasma that is converted into active thrombin during coagulation.

    • ‘Contact with tissue factor triggers the coagulation cascade, resulting in the conversion of prothrombin to active thrombin.’
    • ‘Indicated tests include a complete blood cell count with platelet count, a peripheral blood smear, and prothrombin and activated partial thromboplastin times.’
    • ‘This complex activates prothrombin to thrombin in the presence of calcium ions.’
    • ‘Years ago we said fibrinogen (a soluble protein) becomes a clot of insoluble fibrin by the action of thrombin made from soluble prothrombin in the presence of calcium.’
    • ‘The next to last step in this chain is the activation of the circulating proenzyme prothrombin into its active form, thrombin.’