Which Joe gave his name to ‘sloppy joes’? We look at five interesting sandwiches and their lexical origins.
A biologically inactive compound that can be metabolized in the body to produce a drug.
- ‘While remaining innocuous to the normal tissues, the prodrug is converted to the cytotoxin by the enzyme localised at the tumour.’
- ‘An ester prodrug was shown to increase the bioavailability of MPA following oral administration.’
- ‘At Cardiff, she is promoting a more proactive role for polymers: ‘as integral parts of therapeutics, which could be thought of as macromolecular prodrugs, or even as drugs in their own right’.’
- ‘A second important aspect of the invention is to have the second binding head capture or contain an enzyme that activates a prodrug substrate.’
- ‘As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby.’
- ‘This involves gene transfer of an enzyme into tumour cells, which converts an inactive prodrug into a toxic metabolite, leading to cell death.’
- ‘The influence of branching on the enzymatic stability of the compounds was investigated, as it is known that sterically hindered ester prodrugs are more stable toward enzymatic hydrolysis.’
- ‘It is a prodrug that is converted intracellularly to various metabolites that bind to the enzyme thymidylate synthase, inhibiting synthesis of thymidine, DNA, and RNA.’
- ‘The antihistamine loratidine is one example of a prodrug that must be activated by liver enzymes to be effective, the researchers pointed out in their paper.’
- ‘The improvement of bioavailability of ALA by application of ALA esters is determined by two processes: the rate of diffusion of the prodrug through the cell membrane and its rate of enzymatic conversion into ALA.’
- ‘In addition, the drugs which can increase GSH content, such as cysteine prodrugs, will also reduce acetaminophen hepatotoxicity.’
- ‘ALA is a prodrug and is being used as a photodynamic diagnosis agent in head and neck cancers.’
- ‘The use of targeting antibodies conjugated to enzymes that selectively activate antineoplastic prodrugs on or near cancer cells (known as antibody-directed enzyme prodrug therapy, or ADEPT) is also addressed.’
- ‘Bouncing powerful X-rays off the protein crystals yielded a three-dimensional image of the dual protein structure, showing them exactly how the prodrug and the enzyme interact.’
- ‘In summary, this study has confirmed quantitatively the considerable degree to which the delivery of the ALA prodrug can be enhanced by iontophoresis of the simple, cationic alkyl esters at neutral pH.’
- ‘They waited a bit to give the unbound nanobodies time to filter out of the body, then injected the prodrug.’
- ‘Valacyclovir, a prodrug that metabolizes to acyclovir, has better bioavailability and requires less frequent dosing than acyclovir.’
- ‘Cefuroxime axetil is the ester prodrug of cefuroxime sodium, suitable for oral administration.’
- ‘Codeine, a prodrug, depends on P450 metabolism to morphine for its analgesic effect.’
- ‘Here the enzyme lays dormant until non-toxic drugs, called prodrugs, are given.’
Are you looking for a word for a foolish person? We explore twelve interesting words to describe the dunderheads in your life.
Before you run for the hills, let’s run through a list of ‘run’ expressions that are running through our minds.
The definitions of ‘buddy’ and ‘bro’ in the OED have recently been revised. We explore their history and increase in popularity.