One of the mysteries of the English language finally explained.
An abnormal small chromosome sometimes found in the leukocytes of leukemia patients.
- ‘CML is caused by the errant swapping of genetic material in bone marrow stem cells that produces an abnormality called the Philadelphia chromosome.’
- ‘The classic example of a genetic mutation, and the first identified in the study of human malignancy, is the Philadelphia chromosome, characteristic of chronic myelocytic leukemia.’
- ‘A 27-year-old man had a known history of chronic myeloid leukemia with positive Philadelphia chromosome.’
- ‘The malignant transformation results from a reciprocal translocation between chromosomes 9 and 22, producing a short chromosome known as the Philadelphia chromosome.’
- ‘CML is caused by the breakage and swapping of chromosomes 9 and 22, which results in a shortened chromosome called the Philadelphia chromosome.’
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