One of the mysteries of the English language finally explained.
A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
- ‘For beta 1 selectivity, a beta-adrenergic antagonist should contain a p-substituted aryloxypropanolamine pharmacophore.’
- ‘The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.’
- ‘This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.’
- ‘The particular parts of a drug that cause it to bind to its receptor are together termed the pharmacophore.’
- ‘The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.’
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