One of the mysteries of the English language finally explained.
A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
- ‘This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.’
- ‘The particular parts of a drug that cause it to bind to its receptor are together termed the pharmacophore.’
- ‘For beta 1 selectivity, a beta-adrenergic antagonist should contain a p-substituted aryloxypropanolamine pharmacophore.’
- ‘The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.’
- ‘The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.’
Top tips for CV writingRead more
In this article we explore how to impress employers with a spot-on CV.