Definition of penicillinase in English:



  • An enzyme which can inactivate penicillin, produced by certain bacteria.

    • ‘A control gene regulates the production of an enzyme that destroys the antibiotic, e.g. penicillinase which destroys penicillin.’
    • ‘For example, the resistance to penicillin initially was due to production of an enzyme penicillinase by bacteria, antibiotics like cloxallin were developed which was resistant to penicillinase enzyme.’
    • ‘Penicillin was first used in the early 1940s and by 1950, most Staphylococcus aureus organisms were resistant to the drug by virtue of elaboration of a penicillinase enzyme.’
    • ‘After all, the resistant strain has the genetic information necessary to produce penicillinase, which is a complex chemical.’
    • ‘These chemically modified penicillins have a side chain that inhibits the action of penicillinase.’