1A chronic disease of elderly people characterized by deterioration of bone tissue, especially in the spine, skull, or pelvis, sometimes causing severe pain.Also called osteitis deformans
- ‘Patients with bone pain caused by Paget's disease usually describe the pain as continuous.’
- ‘Because of their relative safety, bisphosphonates have been labeled (for more than two decades) for the treatment of metabolic bone disorders such as Paget's disease.’
- ‘Conditions such as an uncorrected fracture of the shin bone, rheumatoid arthritis, osteoarthritis or Paget's disease can distort the ends of the bones and cause knock knee in adults.’
- ‘The radiologist reported changes consistent with Paget's disease of the bone.’
- ‘It is indicated for the treatment of osteoporosis in post-menopausal women and the treatment of Paget's disease of bone.’
2An inflammation of the nipple associated with breast cancer.
- ‘A rash, redness, scaliness around the nipple or itching that lasts several weeks could also be a sign of eczema or Paget's disease, a rare form of breast cancer.’
- ‘A prolonged rash or irritation of the nipple may indicate a special kind of breast cancer called Paget's disease, which specifically affects the nipple.’
- ‘In about half of the cases of Paget's disease there is a lump which indicates that the underlying cancer is more developed.’
- ‘You are correct to worry that a rash on the nipple areola area could be Paget's disease, but if the nipple itself is not involved this is much less likely.’
- ‘The rash might have been eczema or dermatitis, but its location made me worry about Paget's disease of the breast.’
Late 19th century: named after Sir James Paget (1814–99), English surgeon.