Definition of Paget's disease in US English:

Paget's disease


  • 1A chronic disease of elderly people characterized by deterioration of bone tissue, especially in the spine, skull, or pelvis, sometimes causing severe pain.

    Also called osteitis deformans
    • ‘Patients with bone pain caused by Paget's disease usually describe the pain as continuous.’
    • ‘The radiologist reported changes consistent with Paget's disease of the bone.’
    • ‘It is indicated for the treatment of osteoporosis in post-menopausal women and the treatment of Paget's disease of bone.’
    • ‘Because of their relative safety, bisphosphonates have been labeled (for more than two decades) for the treatment of metabolic bone disorders such as Paget's disease.’
    • ‘Conditions such as an uncorrected fracture of the shin bone, rheumatoid arthritis, osteoarthritis or Paget's disease can distort the ends of the bones and cause knock knee in adults.’
  • 2An inflammation of the nipple associated with breast cancer.

    • ‘A prolonged rash or irritation of the nipple may indicate a special kind of breast cancer called Paget's disease, which specifically affects the nipple.’
    • ‘You are correct to worry that a rash on the nipple areola area could be Paget's disease, but if the nipple itself is not involved this is much less likely.’
    • ‘In about half of the cases of Paget's disease there is a lump which indicates that the underlying cancer is more developed.’
    • ‘A rash, redness, scaliness around the nipple or itching that lasts several weeks could also be a sign of eczema or Paget's disease, a rare form of breast cancer.’
    • ‘The rash might have been eczema or dermatitis, but its location made me worry about Paget's disease of the breast.’


Late 19th century: named after Sir James Paget (1814–99), English surgeon.


Paget's disease

/ˈpædʒəts dəˌziz//ˈpajəts dəˌzēz/