Definition of out of one's skull in US English:

out of one's skull

phrase

informal
  • 1Out of one's mind; crazy.

    • ‘I think you're out of your skull for coming back.’
    • ‘‘I knew I would go out of my skull if I didn't work,’ she says.’
    • ‘When Rhi moved in I was very ill, depressed out of my skull, afraid of the world and generally an apathetic blob.’
    • ‘Anyone who seriously thought Lord Of The Rings was going to win the top honours is out of their skull.’
  • 2Very drunk.

    • ‘I hope Elvis was wasted out of his skull and bought it as a joke, but that's wishful thinking.’
    • ‘People can feel there is nothing to identify with but David Beckham, and all that's left is to get out of your skull on drugs and alcohol.’
    • ‘Emil's drunk out of his skull and Lexi's scared to death.’
    • ‘I'm in Canada, and drunk out of my skull, mind you, so ignore me. / / thread rot…’
    • ‘‘He was clearly out of his skull on drugs,’ he said.’
    • ‘She's the responsible one, even when she's hammered out of her skull.’
    • ‘I was bored out of my skull listening to about two and a half hours of the above.’
    intoxicated, inebriated, drunken, befuddled, incapable, tipsy, the worse for drink, under the influence, maudlin
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