Definition of osteogenesis imperfecta in US English:

osteogenesis imperfecta


  • An inherited disorder characterized by extreme fragility of the bones.

    • ‘Three children with severe osteogenesis imperfecta received allogeneic bone marrow transplants; in two osteoblast engraftment was shown.’
    • ‘In a recent study in Nature Medicine, normal bone marrow derived cells that were infused into patients suffering from osteogenesis imperfecta, a genetic disease.’
    • ‘For example, children with an inherited condition known as osteogenesis imperfecta have bones that are brittle and more susceptible to breaking.’
    • ‘Kwanini, who suffers from osteogenesis imperfecta (brittle bone disease), has been in a wheelchair since the age of nine.’
    • ‘Various clinical conditions such as osteomalacia, osteoporosis, and osteogenesis imperfecta bear witness to the inadequacies of poorly formed bone in fulfilling the role of support to the human body.’


Modern Latin, from osteogenesis + Latin imperfecta ‘imperfect’ (feminine of imperfectus).


osteogenesis imperfecta

/ästēōˌjenəsəs impərˈfektə/