One of the mysteries of the English language finally explained.
A synthetic drug used in treating obesity which is an inhibitor of gastric and pancreatic lipase activity, reducing the proportion of dietary fat that is digested sufficiently to be absorbed; tetrahydrolipstatin, C₂₉H₅₃NO₅. [A trademark for this drug is Xenical.]
1990s; earliest use found in Atlanta Journal and Constitution. From or-, of unknown origin + -listat, alteration of lipstatin, from which the drug is manufactured.
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