Definition of oncogene in US English:



  • A gene which in certain circumstances can transform a cell into a tumor cell.

    • ‘Human herpesvirus 8 contains three potential oncogenes that can transform cell lines in vitro.’
    • ‘This mechanism has been shown to be operational in the case of various oncogenes and tumour suppressor genes.’
    • ‘If those mutations happen to be in oncogenes or tumor suppressor genes and they accumulate over time, it might cause a skin cancer to develop.’
    • ‘Thus the presence of p53 mutation may trigger precipitate the derailment of the cell cycle machinery, rendering cells susceptible to additional aberrations in other important oncogenes and tumour suppressor genes.’
    • ‘In addition, the work is the first to show that a class of proteins called steroid receptors, of which the androgen receptor is a member, can become cancer-causing genes known as oncogenes.’
    • ‘During these events, cells will carry multiple genetic alterations including inactivation of tumor suppressor genes and activation of oncogenes that will help the escape of the cells from normal growth control.’
    • ‘The researchers first discovered the fusion protein acts like an oncogene, or cancer-causing gene, that can promote unrestricted cell growth.’
    • ‘In contrast, the chapter on cancer cytogenetics essentially assumes that the reader possesses an understanding of the concepts of oncogenes and tumor suppressor genes and their applications in cytogenetics.’
    • ‘Ptch is the gene responsible for NBCCS.9,10 However, to our knowledge no studies have examined OKCs for DNA damage in other known tumor suppressor genes or tumor oncogenes.’
    • ‘One study has involved a group of closely related developmental genes, the Ras oncogenes.’
    • ‘Recent studies have been investigating these conditions for the presence of specific translocations and the expression of oncogenes and tumour suppressor genes.’
    • ‘This difference indicates a striking increase in selection against nonsynonymous substitutions in oncogenes and tumor suppressor genes.’
    • ‘The genes found to undergo genetic alterations in cancer have been placed into two categories: oncogenes and tumor suppressor genes.’
    • ‘Thus, most hereditary cancer syndromes are the result of inherited mutations in tumor suppressor genes rather than oncogenes.’
    • ‘Interaction between metabolites of chemical carcinogens, such as polycyclic aromatic hydrocarbons, and DNA can cause mutation in oncogenes and tumor suppressor genes which is believed to initiate the carcinogenic process.’
    • ‘Many cancers result from the acquisition of mutations in a family of genes called oncogenes, which normally serve important housekeeping functions for our cells.’
    • ‘Cellular oncogenes are generally genes that promote normal replication, and as such they are under tight regulatory control to prevent abberant growth.’
    • ‘However, they point out that several genes, including potential oncogenes and tumor suppressor genes, failed to revert to never-smoker levels even after 30 years of cessation.’
    • ‘Much effort in cancer research has gone into identifying and investigating the key genes known as oncogenes; when mutated to high activity, oncogenes stimulate the cell to form cancers.’
    • ‘These are mutations frequently detected in oncogenes or tumour suppressor genes from human tumours.’