Definition of nifedipine in US English:



  • A synthetic compound which acts as a calcium antagonist and is used as a coronary vasodilator in the treatment of cardiac and circulatory disorders.

    • ‘Treatment with long-acting nifedipine failed to lower her pressure, so atenolol, then hydrochlorothiazide, and finally lisinopril were added.’
    • ‘Other topical treatments, including nifedipine and diltiazem, have shown some success.’
    • ‘If this patient has uncomplicated Raynaud's, advise her to wear gloves in cold weather and to avoid tobacco; she may benefit from vasodilators, such as nifedipine 20 mg daily and increased slowly as necessary.’
    • ‘At latest follow-up, the patient was still on clonidine, metoprolol, nifedipine, cyclophosphamide, prednisone, and thalidomide.’
    • ‘I discontinued her thiazide diuretic and substituted nifedipine.’


1970s: from ni(tro-) + fe (alteration of phenyl) + di- + p(yrid)ine, elements of the systematic name.