Definition of neurosyphilis in US English:



  • Syphilis that involves the central nervous system.

    • ‘Tertiary syphilis or neurosyphilis should be treated with penicillin G sodium, 3 million units IV every 4 hours for 10 to 14 days, followed by penicillin G benzathine, 2.4 million units IM weekly for 3 weeks.’
    • ‘The clinical manifestations of neurosyphilis include seizures, ataxia, aphasia, paresis, hyperreflexia, personality and cognitive changes, visual changes, hearing loss, neuropathy, and loss of bowel and bladder functions.’
    • ‘Patients with treatment failure should be tested for HIV infection and evaluated for neurosyphilis with a cerebrospinal fluid examination.’
    • ‘Tertiary or late syphilis is classified into gummatous syphilis, cardiovascular syphilis, and neurosyphilis.’
    • ‘A lumbar puncture is not recommended for routine evaluation, but should be considered for patients with suspected neurosyphilis, cerebral vasculitis, HIV infection, slow-virus diseases, or cerebral Lyme disease.’