Definition of neostigmine in US English:



  • A synthetic compound that inhibits cholinesterase and is used to treat ileus, glaucoma, and myasthenia gravis.

    • ‘This inhibition was observed in both the directly and indirectly stimulated contractions, and was not changed by addition of neostigmine, an acetylcholine esterase inhibitor.’
    • ‘To reverse the muscle relaxation, neostigmine and atropine were used at the end of surgery.’
    • ‘The use of neostigmine to antagonise neuromuscular blockade may increase bowel motility and result in a higher rate of anastomotic leakage.’
    • ‘At the end of procedures, the neuromuscular blockade was reversed, if necessary, with neostigmine, 0.03 mg/kg, and atropine, 0.015 mg/kg.’
    • ‘The study was terminated with the administration of atropine and neostigmine to reverse muscle paralysis.’


1940s: from neo- ‘new’, on the pattern of physostigmine.