Definition of monogenic in US English:



  • Involving or controlled by a single gene.

    • ‘Classical genetics of human disease deals with monogenic disorders in which a single mutation in a single gene is causatively related to the phenotype.’
    • ‘A large number of genes have been described and assigned to specific locations among the 12 chromosomes, and numerous monogenic mutants are available.’
    • ‘The inheritance of apospory has been investigated in a considerable number of plant species and, remarkably, is always inherited as a monogenic dominant trait.’
    • ‘Another difficulty when working with agronomically relevant traits is that many quantitative traits are not inherited in a monogenic manner but are controlled by multiple genes.’
    • ‘A monogenic inheritance is unlikely when considering the low prevalence and high frequency of the suspected disease locus.’