Definition of mono- in US English:

mono-

(also mon-)

combining form

  • 1One; alone; single.

    ‘monorail’
    1. 1.1 With an extreme, singular character to the point of dominance or exclusion.
      ‘monolithic’
      ‘monomania’
      ‘monopoly’
  • 2Chemistry
    (forming names of compounds) containing one atom or group of a specified kind.

    ‘monoamine’

Origin

From Greek monos ‘alone’.

Pronunciation

mono-

/ˈmɑnoʊ//ˈmänō/