Definition of methemoglobin in US English:

methemoglobin

(British methaemoglobin)

Pronunciation /ˌmetˌhēməˈɡlōbən//metˈhēməˌɡlōbən/

noun

Biochemistry
  • A stable oxidized form of hemoglobin which is unable to release oxygen to the tissues, produced in some inherited abnormalities and by oxidizing drugs.

    • ‘In addition, the enzyme systems for reducing methemoglobin to oxyhemoglobin are incompletely developed in infants under six months of age.’
    • ‘In the normal physiological state, small amounts of methemoglobin are formed during the reaction between oxygen and hemoglobin, but these amounts are typically limited to less than 0.02 of the total amount of hemoglobin.’
    • ‘Methemoglobinemia is detectable by measurement of blood levels of methemoglobin and is manifested clinically as cyanosis and hypoxia.’
    • ‘Red cells are lysed and potassium ferricyanide oxidizes hemoglobin to methemoglobin, which combines with potassium cyanide forming cyanmethemoglobin.’
    • ‘Patients with red cell breakdown, for example in malaria, pass haemoglobin into the urine, where it is broken down to the brown pigment methaemoglobin; hence one form of malaria is called ‘black-water fever’.’

Pronunciation

methemoglobin

/ˌmetˌhēməˈɡlōbən//metˈhēməˌɡlōbən/