Definition of mescalism in US English:

mescalism

noun

rare
  • The practice of taking mescal or mescaline; the state of intoxication resulting from this.

Origin

Early 20th century; earliest use found in American Anthropologist. From mescal or mescal- + -ism.

Pronunciation

mescalism

/ˈmɛskəlɪz(ə)m/