One of the mysteries of the English language finally explained.
A piperazine derivative, C₂₅H₂₇ClN₂, with antihistamine properties, used mainly as an anti-emetic, especially in preventing motion sickness. [Meclozine is the International Nonproprietary Name and British Approved Name; meclizine is the name in the Pharmacopeia of the U.S.A.]
1950s; earliest use found in Journal of Pharmacological and Experimental Therapeutics. Apparently earliest as meclizine from me- + -clizine. In form meclozine perhaps remodelled after hydrochloride.
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