Definition of Marfan's syndrome in US English:

Marfan's syndrome

(also Marfan syndrome)


  • A hereditary disorder of connective tissue, resulting in abnormally long and thin digits and also frequently in optical and cardiovascular defects.

    • ‘None had had a previous aortic dissection or had a family history or clinical characteristics of Marfan's syndrome, and in no case was the aortic dissection secondary to chest trauma.’
    • ‘Causes of dissection include hypertension, Marfan's syndrome, trauma, Ehler's Danlos, coarctation, bicuspid aortic valve and relapsing polychondritis.’
    • ‘Younger patients with Marfan's syndrome may benefit from surgery in the subacute phase and avoid rupture of a residual saccular aneurysm in the future.’
    • ‘Orthodontists also play a role in diagnosing systemic conditions that affect facial growth or development of the dentition, such as acromegaly or Marfan's syndrome.’
    • ‘Most interest has been focused on fibrillin, since it is present in the largest amounts and since mutations in the fibrillin gene are responsible for Marfan's syndrome.’


1930s: named after Antonin B. J. Marfan (1858–1942), French pediatrician.


Marfan's syndrome