Definition of Mandrax in US English:



  • A sedative drug containing methaqualone and diphenhydramine hydrochloride.

    • ‘The initial effects of Mandrax may include feelings of euphoria, a brief loss of consciousness, nausea, and stupor.’
    • ‘Dagga and Mandrax remain the biggest problem drugs in South Africa, according to Central Drug Authority chairman Frank Kahn.’
    • ‘Indications are that they were sold by drug addict thieves desperate for Mandrax.’
    • ‘Such a person's body has developed a tolerance to Mandrax and needs to use more to reach the same effects.’
    • ‘Across sites, Mandrax was the second most commonly detected drug, with approximately one in five arrestees testing positive for this substance.’


1960s: of unknown origin.