Definition of major histocompatibility complex in English:

major histocompatibility complex

(also MHC)

noun

  • A genetic system that allows large proteins in immune system cells to identify compatible or foreign proteins. It allows the matching of potential organ or bone marrow donors with recipients.

    • ‘Attempts to identify sarcoidosis susceptibility genes have focused on the genes residing in the major histocompatibility complex, particularly the HLA genes.’
    • ‘The MS gene belongs to the major histocompatibility complex.’
    • ‘The classic example of genetic variation in the immune system is the major histocompatibility complex on chromosome 6.’
    • ‘The host's major histocompatibility complex is the part of the immune system that presents antigens to various immune system cells.’
    • ‘This would be consistent with evolution of variation in the major histocompatibility complex of the human immune system by infectious agents.’
    • ‘The major histocompatibility complex is a multigene family identified across a range of vertebrate species.’