Definition of lipodystrophy syndrome in US English:

lipodystrophy syndrome


  • A metabolic disease in which fat distribution in the body becomes abnormal, often as a result of taking protease inhibitor drugs. Fat is lost from the face, arms, and legs, and is built up in other places, especially the breasts, abdomen, and back of the neck.

    • ‘Various definitions of the lipodystrophy syndrome exist and different diagnostic tools are used.’
    • ‘The main clinical features of the lipodystrophy syndrome are peripheral fat loss, central fat accumulation and metabolic abnormalities which lead to lactoacidosis.’
    • ‘The evolution of the individual clinical components of the lipodystrophy syndrome is variable.’
    • ‘Such findings may have relevance for the common insulin resistance syndrome and for acquired lipodystrophy syndromes.’
    • ‘This article will review the basic information that is leading scientists and researchers to suspect mitochondrial toxicity as a factor in lipodystrophy syndrome.’


lipodystrophy syndrome