Definition of ligation in US English:



  • 1The surgical procedure of closing off a blood vessel or other duct or tube in the body by means of a ligature or clip.

    ‘the ligation of the cystic duct’
    • ‘In most centres, surgical ligation is reserved for instances where the ductus remains open despite pharmacological treatment.’
    • ‘The haemorrhage is life threatening and surgical ligation or endovascular occlusion of the common carotid is usually required.’
    • ‘Oral contraceptives, tubal ligation, and pregnancy lower the risk of ovarian cancer.’
    • ‘Rarely, perineal sepsis occurs as a complication of rubber band ligation of internal hemorrhoids.’
    • ‘Many perioperative nurses, however, can recall an incident of wrong site surgery, retained instruments, unintentional ligation of the ureter, unintentional nicking of an artery or organ, or some other misadventure during surgery.’
    • ‘The occlusion rates are close to 100 %, higher than published results for surgical ligation.’
    • ‘Mediastinal exploration for the removal of a hematoma on a patient with a ventricular assist device and ligation of a patent ductus arteriosus are two types of procedures that occasionally are performed in the ICU rather than the OR.’
    • ‘Past surgical history was also remarkable for endoscopic band ligation of the GI vascular malformations which was unsuccessful.’
    • ‘After ligation of the right coronary artery, bypass grafting with a saphenous vein was performed.’
    • ‘Plastic surgeons advise excision of the involved area down to fascia and ligation of associated perforating blood vessels followed by split-thickness skin grafts, but lesions often recur within or around the graft.’
    • ‘Because of individual differences in training and experience, we are not surprised that physicians who perform this procedure are often divided on the issue of clipping versus ligation.’
    • ‘In developed countries laparoscopic tubal ligation is usually performed under general anaesthesia.’
    • ‘Tubal ligation involves closing off the fallopian tubes in a woman so that eggs cannot reach the uterus.’
    • ‘One hospital transfer is accounted to each of the following procedures: circumcision, cystoscopy, hemorrhoid ligation and vasectomy reversal.’
    • ‘Endoscopic ligation can be repeated every 4-6 weeks until the esophageal varices have all been obliterated.’
    • ‘Failure to recognize such aberrant ductal anatomy may lead to potential ligation of ducts during surgery.’
    • ‘The occlusion rates are close to 100%, higher than published results for surgical ligation.’
    • ‘A left lower lobectomy with arterial ligation was performed.’
    • ‘Treatments vary from radiological ablation to surgical ligation of the varicocele, although most urologists reserve the radiological approach for the rare surgical failures.’
    • ‘Patients having greater saphenous incompetence may undergo ligation and division of the greater saphenous vein.’
  • 2Biochemistry
    The joining of two DNA strands or other molecules by a phosphate ester linkage.

    • ‘The cut DNAs were ligated at low concentrations, to encourage intramolecular ligation reactions.’
    • ‘A mechanism leading to tandem sequence duplication may involve DNA damage followed by DNA synthesis, strand displacement, and ligation.’
    • ‘The ligation reactions were used as template DNA for one of the following methods.’
    • ‘Ligations were performed and prepared for transformation as previously described.’
    • ‘The complete stoned cDNA was obtained by ligation of fragments from three different cDNA clones.’


Late Middle English: from late Latin ligatio(n-), from the verb ligare (see ligate).