An enzyme that brings about ligation of DNA or another substance.→ synthase
- ‘The E.coli bacterium has an enzyme, DNA ligase, which can be used to repair these nicks in the sugar-phosphate backbone of DNA chains to form an intact double-strand.’
- ‘After all, in nature we can and do observe bacteria using restriction endonucleases and ligases to cut DNA.’
- ‘These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.’
- ‘This study shows that in a competition between the two enzymes, DNA ligase trumps the flap endonuclease in capturing bubbles and creating expanded tracts.’
- ‘A number of conjugating enzymes and protein ligases are in the cell, and various combinations confer substrate specificity on the system.’
1960s: from Latin ligare to bind + -ase.