Definition of kinetochore in US English:



  • 1A complex of proteins associated with the centromere of a chromosome during cell division, to which the microtubules of the spindle attach.

    • ‘In metaphase, sister kinetochores attach to microtubules emanating from opposite spindle pole bodies during alignment of the chromosomes.’
    • ‘The DNA is asymmetrically distributed to the daughter cells when the kinetochores do not attach and the spindle checkpoint does not restrain mitosis.’
    • ‘A second checkpoint pathway, the spindle checkpoint, operates at a similar point in meiosis, preventing progression into anaphase if the spindle apparatus fails to connect appropriately with kinetochores.’
    • ‘Chromosome loss may be the result of either non-attachment of the chromosome kinetochore to the spindle microtubules or chromosome lagging at anaphase and gives rise to a micronucleus.’
    • ‘This cohesion or ‘chiasma binder’ function ensures the generation of a bipolar spindle in which tension is generated at the kinetochores.’
    1. 1.1historical
      another term for centromere


1930s: from kineto- ‘of movement’ + Greek khōros ‘place’.