Definition of James River in US English:

James River

proper noun

  • 1A river that flows for 700 miles (1,100 km) from North Dakota through South Dakota into the Missouri River.

    Also called Dakota River
  • 2A river that flows for 340 miles (550 km) across eastern Virginia, past Richmond, and into the Tidewater region into Hampton Roads. Colonial Jamestown was on its estuary.