One of the mysteries of the English language finally explained.
A synthetic isomer of tretinoin used in topical and oral forms in the treatment of severe acne. [Isotretinoin is 13-cis-retinoic acid. It is a known teratogen. A trademark for this drug is Ro-accutane.]
1970s; earliest use found in Journal of the American Medical Association. From iso- + tretinoin.
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