Definition of in silico in US English:

in silico

adjective & adverb

  • (of scientific experiments or research) conducted or produced by means of computer modeling or computer simulation.

    as adjective ‘in silico analysis of the human genome’
    adverb ‘students who are too squeamish to dissect a frog can perform the procedure in silico’
    • ‘In silico screening of the available genome sequences corroborated results.’
    • ‘In silico analysis is not straight-forward either, but presents a necessary extension to current in vitro methods.’
    • ‘In silico strategies can be used to investigate the potential roles of a mutation on, for instance, protein stability.’
    • ‘In silico analyses were completed to provide information about the possible cellular location of the protein.’
    • ‘In silico results corroborated published laboratory findings.’
    • ‘This enables us to replicate cells in silico: we can simulate an increasing population of cells.’
    • ‘In silico experiments can now be done on a wide variety of systems without the practical limitations that one may face in experimental approaches.’
    • ‘We examine the essence by reconstituting it in silico.’
    • ‘In silico propagation of the charged particles yielded passage time values that are compatible with the measured average passage time of ions.’
    • ‘This in silico approach would be helpful in ranking textile dyes of the different classes based on their binding affinities.’


1980s: Latin, literally ‘in silicon’ (with reference to the use of silicon chips in computer systems), on the pattern of in vitro and in vivo.


in silico

/in ˈsiləˌkō/