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1Having reduced pressure or tone, in particular.
- ‘Following hypotonic treatment and fixation, the cells are dropped on a slide and then stained.’
- ‘First, hypotonic treatment did not change surface adhesiveness.’
- ‘More commonly, hypotonic loss is seen related to gastrointestinal sources, burns, diuretic therapy or osmotic diuresis.’
- ‘Cell harvesting and slide preparation followed standard cytogenetic procedures involving hypotonic treatment, fixation and staining.’
- ‘A potential limitation of the presented methods is that pressure-flow measurements were generated under hypotonic conditions.’
- ‘Vasopressin continued to act in patients excreting isotonic or hypertonic urine, so hypotonic intake must be avoided in them.’
- ‘In IMCD cells all cellular organic osmolytes leave the cells under hypotonic conditions.’
- ‘More severe reactions such as persistent crying, seizures, and hypotonic hyporesponsiveness are rare.’
- ‘All seven mutants that failed to rescue the cell from hypotonic shock did not show channel activity under patch clamping.’
- ‘However, in vivo sampling methods lead to the stimulation of a relatively hypotonic glandular secretion.’
- 1.1Biology Having a lower osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid.
- ‘At the end of the culture period cells were harvested, exposed to a hypotonic solution and fixed in methanol/acetic acid.’
- ‘To collect the cells, the cultures were centrifuged and treated with hypotonic solution for 30 min at 37°C.’
- ‘After 15 min five drops of methanol/acetic acid were added to the hypotonic solution to begin cell fixation.’
- ‘About 5 ml of hypotonic solution was added.’
- ‘Thus, the photodamaged lysosomes and the normal ones will suffer the same level of osmotic stress in the same hypotonic sucrose medium.’
- 1.2Physiology Of or in a state of abnormally low muscle tone.
- ‘On arrival, at 3 hours of age, he was hypotonic with tonic seizures of the upper extremities and bilaterally fixed, dilated pupils.’
- ‘The infant with botulism becomes progressively weak, hypotonic and hyporeflexic, showing bulbar and spinal nerve abnormalities.’
- ‘Cerebral palsy takes the form of a hypotonic tetraplegia when the child has a mobility problem but with floppy muscles.’
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