Definition of hypotonic in English:



  • 1Having reduced pressure or tone, in particular.

    • ‘Following hypotonic treatment and fixation, the cells are dropped on a slide and then stained.’
    • ‘First, hypotonic treatment did not change surface adhesiveness.’
    • ‘More commonly, hypotonic loss is seen related to gastrointestinal sources, burns, diuretic therapy or osmotic diuresis.’
    • ‘Cell harvesting and slide preparation followed standard cytogenetic procedures involving hypotonic treatment, fixation and staining.’
    • ‘A potential limitation of the presented methods is that pressure-flow measurements were generated under hypotonic conditions.’
    • ‘Vasopressin continued to act in patients excreting isotonic or hypertonic urine, so hypotonic intake must be avoided in them.’
    • ‘In IMCD cells all cellular organic osmolytes leave the cells under hypotonic conditions.’
    • ‘More severe reactions such as persistent crying, seizures, and hypotonic hyporesponsiveness are rare.’
    • ‘All seven mutants that failed to rescue the cell from hypotonic shock did not show channel activity under patch clamping.’
    • ‘However, in vivo sampling methods lead to the stimulation of a relatively hypotonic glandular secretion.’
    1. 1.1Biology Having a lower osmotic pressure than a particular fluid, typically a body fluid or intracellular fluid.
      • ‘At the end of the culture period cells were harvested, exposed to a hypotonic solution and fixed in methanol/acetic acid.’
      • ‘To collect the cells, the cultures were centrifuged and treated with hypotonic solution for 30 min at 37°C.’
      • ‘After 15 min five drops of methanol/acetic acid were added to the hypotonic solution to begin cell fixation.’
      • ‘About 5 ml of hypotonic solution was added.’
      • ‘Thus, the photodamaged lysosomes and the normal ones will suffer the same level of osmotic stress in the same hypotonic sucrose medium.’
    2. 1.2Physiology Of or in a state of abnormally low muscle tone.
      • ‘On arrival, at 3 hours of age, he was hypotonic with tonic seizures of the upper extremities and bilaterally fixed, dilated pupils.’
      • ‘The infant with botulism becomes progressively weak, hypotonic and hyporeflexic, showing bulbar and spinal nerve abnormalities.’
      • ‘Cerebral palsy takes the form of a hypotonic tetraplegia when the child has a mobility problem but with floppy muscles.’