Abnormal thickening of the outer layer of the skin.
- ‘Skin biopsy typically reveals hyperkeratosis and follicular plugging, with superficial and deep lymphocytic infiltrates.’
- ‘Most leukoplakias are caused by hyperkeratosis or a thickening of the outer keratin layer.’
- ‘Their clinical symptoms were primarily hyperkeratosis and hyperpigmentation, which are well-recognized signs of arsenicalism.’
- ‘Corns and calluses result from hyperkeratosis, a normal physiologic response of the skin to chronic excessive pressure or friction.’
- ‘The most common pattern of oral disease reveals a reticular network of white hyperkeratosis on the buccal mucosa.’