Definition of how do you do? in US English:

how do you do?

phrase

  • A formal greeting.

    • ‘In Eliza's first venture into polite company, she comes off as an automaton relegated to a handful of standard phrases and topics: the weather, people's health and ‘how do you do?’’
    • ‘‘There hasn't even been a preliminary ‘Hey, how do you do?’’
    • ‘He used to kick off his act with ‘Hello, playmates, how do you do?’’
    • ‘I'm Jen, the captain of the squad, and this is my brother Ryan, how do you do?’