Relating to or denoting an environment for rearing or culturing organisms in which all the microorganisms are either known or excluded.
- ‘The March 30th issue of the Proceedings of the National Academy of Sciences, with a Warholian zebrafish cover, features a study from Washington U. where the fish were raised under strictly aseptic (gnotobiotic) conditions.’
- ‘Recently, however, model systems for examination of the intestinal flora have been made available in the establishment of germ-free, gnotobiotic (known flora) and specific pathogen-free animals.’
- ‘The MUSC Gnotobiotic Research Resource gives investigators at MUSC a unique opportunity to conduct research with germfree (gnotobiotic) animal models, in addition to more widely available specific-pathogen-free animal models.’
1940s: from Greek gnōtos known + biotic.