Definition of general paralysis in US English:

general paralysis

noun

  • (In early use) paralysis involving the whole body; (later) specifically (more fully "general paralysis of the insane") a late manifestation of syphilis in which there is inflammation and atrophy of brain tissue, especially of the frontal and temporal lobes, resulting in a variety of psychiatric and neurological symptoms such as dementia, psychosis, seizures, and generalized muscle weakness; = "paresis". Abbreviated GPI.

Origin

Early 19th century; earliest use found in Edinburgh Medical and Surgical Journal.