Definition of fibrinogen in English:



  • A soluble protein present in blood plasma, from which fibrin is produced by the action of the enzyme thrombin.

    • ‘The thrombin cleaves fibrinogen to an active monomer that polymerizes to form a fibrin meshwork.’
    • ‘This leads to extravasation of fibrinogen and other plasma proteins, activation of the clotting system, and deposition of a fibrin gel in the extravascular space.’
    • ‘This white, fibrous protein is made when thrombin, an enzyme found in blood, reacts with fibrinogen, a protein in blood.’
    • ‘The ultimate effect of this cascade is to convert the soluble protein fibrinogen to the insoluble protein fibrin, which forms the basis of the clot that stops bleeding.’
    • ‘The objective of this complex process is to convert a soluble plasma protein, fibrinogen, to an insoluble fibrin mesh, or blood clot.’