One of the mysteries of the English language finally explained.
The interaction of genes that are not alleles, in particular the suppression of the effect of one such gene by another.
- ‘Neither earlier study was able to demonstrate a significant effect of epistasis, either positive or negative.’
- ‘This advantage of sex should be especially substantial when mutations interact through negative epistasis.’
- ‘For geneticists, epistasis is associated with the limits of the additive model of gene action.’
- ‘These results suggest that future genetic models for the evolution of aging should incorporate the effects of epistasis.’
- ‘Genetic epistasis of gene expression can also be considered with large sample sizes.’
Early 19th century: from Greek, literally ‘stoppage’, from ephistanai ‘to stop’.
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